Following the wild flight that was 2020, where does the market go from here? Major strides have been made in the COVID-19 vaccine race, yet the near-term photo stays unclear, blurred by the infection’ resurgence and the stimulus stalemate on Capitol Hill.In times like these, the investing greats can work as a source of motivation, particularly billionaire Israel “Izzy” Englander.Who precisely is Englander? The legend, who started trading stocks when he remained in high school, began his profession interning at financial investment company Oppenheimer, later on going on to buy a seat on the American Stock Exchange, where he would function as a flooring broker, trader and specialist.In 1989, in addition to Ronald Shear, Englander established hedge fund Centuries Management. As evidence of his outstanding track record, the expert took the $35 million the fund was begun with and turned it into over $40 billion in properties under management. With his individual net worth clocking in at $7.2 billion, it’s no surprise Wall Street pays attention when Englander makes a move.Bearing this in mind, our focus moved to Millenium’s most recent 13F filing, which discloses the stocks the fund bought in the third quarter. Locking in on two tickers in specific, TipRanks’ database exposed that both names score a “Strong Buy” analyst consensus. What’s more, the analyst community sees huge upside possible in shop for each.G1 Therapeutics (GTHX)Bringing a deep understanding of the biology of cancer and substantial drug discovery experience to the table, G1 Therapies works to develop therapies that could potentially enhance the lives of clients fighting the fatal illness. Ahead of a key regulative choice, the Street is pounding the table on this name.During the 3rd quarter, Englander and Millennium got a brand-new stake in GTHX. Pulling the trigger on 555,937 shares, the worth of the holding can be found in at $6,421,000. Relying on the analyst neighborhood, Needham’s Chad Messer informs customers that he has high hopes ahead of the February 15 PDUFA date for trilaciclib, its treatment created to enhance outcomes for cancer patients treated with chemotherapy. The treatment’s NDA was accepted in August for Concern Evaluation based on results from 3 randomized medical studies in small cell lung cancer (SCLC), with the FDA indicating that it doesn’t intend on holding an advisory committee (AdComm) meeting.As trilaciclib is the first CDK4/6 inhibitor to be used to deal with chemo-induced bone marrow toxicity, Messer argues that the absence of an AdComm is “significant.” Expounding on this, he specified, “We believe this shows the agency’s appreciation of the unmet need, convenience with the safety profile of the CDK4/6 class, and effectiveness profile of trilaciclib.”GTHX will likewise focus on the inclusion of trilaciclib into NCCN guidelines. It must likewise be kept in mind that a Stage 3 pivotal study evaluating the candidate in metastatic colorectal cancer (mCRC) is set to kick off by year end.Adding to fortunately, GTHX and its partner, Boehringer Ingelheim, are preparing for the industrial launch of trilaciclib, with the companies covering around 2,500 dealing with oncologists and supplying instructional materials regarding the use of trilaciclib ahead of treatment and the benefits of multi-lineage preservation.If that wasn’t enough, the rintodestrant (its selective estrogen receptor degrader (SERD) in development for the treatment of estrogen receptor-positive (ER+) breast cancer) plus palbociclib mix research study was able to conclude registration earlier than expected, showing “the appeal of an all-oral treatment regimen during an international pandemic,” in Messer’s viewpoint. With a data readout slated for Q2 2021, the expert thinks a “favorable readout could show to be a substantial worth motorist.”In line with his positive method, Messer reiterated a Buy ranking and $74 cost target, suggesting 417% upside possible. (To see Messer’s track record, click here)Are other experts in arrangement? They are. Only Purchase ratings, 3 to be exact, have been provided in the last three months. Therefore, the message is clear: GTHX is a Strong Buy. Offered the $59 typical rate target, shares could increase 312% in the next year. (See GTHX stock analysis on TipRanks)Epizyme (EPZM)Also fighting the great battle against cancer, in addition to against other serious illness, Epizyme wishes to discover new treatments through unique epigenetic medications. Even though the company deals with headwinds with regard to its current product launch, several members of the Street think huge things remain in store.Millenium purchased 461,258 shares during the 3rd quarter, with the buy showing a brand-new position for the hedge fund. When it comes to the value of the holding, it lands at $5,503,000. Composing for Wedbush, 5-star expert David Nierengarten points out that the pandemic has limited oncologist gos to, and for that reason, Tazverik (the business’s follicular lymphoma treatment) sales were lower than he expected. He mentions that “the pandemic shifts the launch curve to an ‘occurrence model’ instead of a frequency model, as there is a restricted patient swimming pool to draw from if they are delaying office sees,” with patients waiting to seek treatment up until they experience signs of progression.Additionally, although the launch is virtual and physician awareness is high, doctors are opposed to prescribing a brand-new medication without analyzing the patient face to face. That being stated, Nierengarten remains optimistic about the treatment.”In spite of these headwinds, Tazverik came close to fulfilling our price quotes, and it is getting market share, including seeing initial sales in second line. We expect more significant 2nd line sales to begin in 2021, and have actually more slowly included them into our launch curve,” the analyst explained.When it comes to the time on therapy, Nierengarten argues it’s too early to come to any conclusions. Nevertheless, he highlights the truth that toughness of action was reasonably long and patients were treated past development in the registration research study. “In addition, the headwind versus switching therapies becomes a tailwind of Tazverik upkeep once a client is on treatment. This will likely contribute more meaningfully to 2H21 incomes and possible income outperformance,” he added.Summing all of it up, Nierengarten commented, “At current levels, we believe investors are too unfavorable on Tazverik’s prospective and persistence should be rewarded.”Based upon all of the above, Nierengarten sides with the bulls, reiterating an Outperform ranking and $27 cost target. This target communicates his self-confidence in EPZM’s ability to climb up 122% greater in the next year. (To enjoy Nierengarten’s performance history, click on this link)A lot of other experts echo Nierengarten’s belief. 3 Buys and 1 Hold add up to a Strong Buy agreement ranking. With a typical cost target of $23.25, the upside potential is available in at 91%. (See EPZM stock analysis on TipRanks)To discover excellent concepts for healthcare stocks trading at appealing assessments, see TipRanks’ Finest Stocks to Purchase, a newly released tool that unifies all of TipRanks’ equity insights.Disclaimer: The viewpoints revealed in this short article are solely those of the included analysts. The content is meant to be used for educational purposes just. It is extremely essential to do your own analysis before making any investment.